| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Ultrasmooth materials-independent surface chemistry and nanodepot for nitric oxide using poly(norepinephrine) |
| 초록 |
Despite the extensive use of polydopamine (pDA) as a coating, the resulting uncontrollable surface morphology after functionalization is still a significant problem associated with pDA surface chemistry. Herein, we report oxidative polymerization of norepinephrine to yield a poly(norepinephrine) (pNE) coating which has nearly perfect smoothness at the nanometer scale. Studies at the Molecular level revealed that a new intermediate, 3,4-dihydroxybenzaldehyde (DHBA), resulted in a remarkable difference in surface morphology compared to pDA. In addition, a novel property was found in which pNE layers can be a universal depot for storing and releasing nitric oxide (NO) as small therapeutics. This property can be useful for various types of biomedical devices which require an NO-releasing functionality. |
| 저자 |
김지훈1, 홍선기2, 이해신3, 김원종4
|
| 소속 |
1Center for Self-assembly and Complexity, 2Institute for Basic Science (IBS) and Department of Chemistry, 3POSTECH, 4카이스트 화학과 |
| 키워드 |
mussel-inspired; poly(norepinephrine); nitric oxide
|
| E-Mail |
|
