| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 가을 (10/23 ~ 10/25, 대구 EXCO) |
| 권호 |
19권 2호, p.1490 |
| 발표분야 |
생물화공 |
| 제목 |
In Vitro Photodynamic Cancer Therapy with Ultra-high Drug Loaded ZnO Hollow Carriers |
| 초록 |
Development of novel, multimodal therapeutic nanocarriers for ultra-high medicine loading holds paramount promises in cancer treatment. Herein, we demonstrate that acid-decomposable ZnO hollow microspheres (ZHM) complexed with daunorubicin (DNR) as a model anticancer drug can be adopted for effective combined chemo-photodynamic cancer therapy. Moreover, ZnO nanorods (ZNR) loaded with DNR was also studied as a comparative material. A remarkable enhanced drug loading capacity was featured by ZHM (~91%), much higher than ZNR. The release of drug from the nanocomplex was pH-dependent and an acidic condition enhanced the drug release rate. In vitro studies showed an increased ZHM-DNR complex uptake by human alveolar adenocarcinoma (A549) cells and the complexes is mainly accumulated in lysosomes and promotes continual drug release and successfully destruct cancer cell. In presence of UV irradiation, the nanocomplex anticancer activity was significantly increased, demonstrated by MTT assay, flow cytometry, apoptosis assay, nuclear DAPI staining, etc. This study suggests ZHM for an efficient multimodal chemotherapeutic agent. |
| 저자 |
Nirmalya Tripathy1, Ahmad Rafiq2, Ko Hyan Aa2, Gilson Khang2, 한윤봉2
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| 소속 |
1전북대, 2Chonbuk National Univ. |
| 키워드 |
Zinc Oxide; Hollow microspheres; Daunorubicin; Photodynamic; Chemotherapeutic
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| E-Mail |
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| 원문파일 |
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