| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Tumoral Acidic pH-Responsive Calcium Carbonate Mineralized Nanoparticles for Efficient Tumor Therapy |
| 초록 |
The extracellular pH of the tumor tissue is significantly lower than that of the normal tissue. Heterogeneous variations of pH within cells and in a tumor have been a target for pH-sensitive drug delivery systems. In this work, we have developed CaCO3 mineralized nanoparticles for tumor therapy. The block copolymer (poly(ethylene glycol)-poly(L-aspartic acid)) (PEG-PAsp) was added during the CaCO3 mineralization. The anionic PAsp block can act as a mineral nucleating template and participated in the formation of the CaCO3 core. The PEG block formed the hydrated shell and may contribute to the prolonged circulation for enhanced permeation and retention (EPR). We also incorporated doxorubicin (DOX), an anticancer drug, within the CaCO3 core during the mineralization process. The pH dependent dissolution behavior of nanoparticles and the pH-dependent DOX release kinetics were examined. The tumor volume was monitored in tumor-bearing mice for antitumor efficacy of DOX loaded nanoparticles. |
| 저자 |
민경현, 구안나, 이홍재, 정서영, 이상천
|
| 소속 |
경희대 |
| 키워드 |
pH-responsive; calciium carbonate; mineralization; tumor therapy
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| E-Mail |
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