| 초록 |
The objective of this study was how to modulate the specific human umbilical vein endothelial cell (HUVEC) adhesion and responses on biomaterials surfaces. Bioactive peptides (RGD, REDV, and LDV ligands) were immobilized on the biocompatible poly(L-lactic acid) (PLLA) films. Biomimetic modifications were carried out by means of two-step reaction process: the creation of carboxyl group by plasma treatment and immobilization of the bioactive peptides. The peptide-immobilized film surface was confirmed from ATR-FTIR, contact angle, ESCA, FE-SEM, and amino acid analysis. The resulting REDV-immobilized PLLA film would be more bioactive and specific for HUVEC attachment. This result suggests that the immobilization of REDV ligand on PLLA film can effective for HUVEC adhesion, migration, and re-endothelization, and it may be helpful to prevent thrombosis and neointimal hyperplasia for vascular stents. |
