| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Near infrared laser-induced drug release of thermoresponsive nanovesicles containing melanin |
| 초록 |
The aim of this study is to induce and control drug release of liposome using near infrared (NIR) laser. In this study, phospholipids and poly-(N-isopropylacrylamide-co-acrylamide) (PNIPAM) composite nanovesicle was prepared and melanin as a photo-heat conversion material was added. The mean diameter of the nanovesicle was 177±14 nm and spherical shape was observed. The nanovesicle was stable in PBS buffer for longer than 7 days. After NIR 808 nm laser irradiation at 1.5 W/cm2 for 7 min, the temperature of nanovesicle solution has increased from 20.5℃ to 51℃. In drug release study, after the laser irradiation, 5-FU loaded into the nanovesicles showed the faster drug release compared with the group not irradiated with the laser. Furthermore, as the amount of PNIPAM increased, the rate of drug release increased more rapidly. The nanovesicle are expected to be useful as a drug delivery carrier for inducing drug release by NIR laser irradiation. |
| 저자 |
김예슬1, 김민아1, 김동운2, 이호준1, 이창문1
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| 소속 |
1전남대, 2광양보건대 |
| 키워드 |
Melanin; Poly(N-isopropylacrylamide-co-acrylamide); Nanovesicle; Drug release; Photothermal effect
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| E-Mail |
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