| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Myogenic Induction of H9C2 Cells Using Aligned Nanofiber with Micropatterned Poly(ethylene glycol) Hydrogel Scaffolds |
| 초록 |
In this study, we fabricated 3D fibrous scaffolds to promote myogenic differentiation of H9C2 cells, myocardium-derived cell line. To create patterned structure, we used poly (ethylene glycol) (PEG) hydrogel and polycaprolactone (PCL) electrospun nanofiber. The resultant micropatterned 3D fibrous scaffold had random, parallel, vertical orientation of nanofiber and hydrogel. This scaffold offered not only biomimetic structures but also suitable environment for cell differentiation by cell morphology change. The results showed that the aligned fibrous network and hydrogel alignment of 3D scaffolds were beneficial to induce myogenesis of H9C2, and efficiency was higher than other systems without alignment of nanofiber or hydrogel. The fabricated multifunctional 3D fibrous scaffold indicates the potential for using practical tissue engineering. |
| 저자 |
차성호, 정의석, 민지홍, 국윤민, 윤병주, 방혜정, 고원건
|
| 소속 |
연세대 |
| 키워드 |
nanofiber; 3D scaffold; myogenesis
|
| E-Mail |
|
