| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
HA-PLGA Nanopaticles for Controlled Release Formulation of Paclitaxel |
| 초록 |
A novel protocol for the preparation of poly(lactic-co-glycolic acid) grafted hyaluronic acid (HA-PLGA) polymeric micelle system was successfully developed for tumor targeting cancer drug delivery. The mean particle size of HA-PLGA, which was in the range of 100 nm ~ 250 nm, could be controlled by changing the reaction conditions. The drug loading capacity measured by HPLC method was ca. 84 % (w/w). In vitro release tests showed the continuous release of paclitaxel up to a month. These novel HA-PLGA nanoparticles incorporating paclitaxel with EPR effect will be further assessed by in vivo release tests. |
| 저자 |
박정규, 한세광
|
| 소속 |
포항공과대 |
| 키워드 |
Hyaluronic acid; HA-PLGA nanopaticles; Paclitaxel; EPR effect
|
| E-Mail |
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