| 학회 | 한국화학공학회 |
| 학술대회 | 2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 | 25권 2호, p.1471 |
| 발표분야 | 생물화공 (Biochemical Engineering) |
| 제목 | Biomimetic hydrogel design for selective permeation of biomolecules |
| 초록 | The nuclear pore is a natural filtering systems which selectively separate biomolecules, with the help of mesh-like hydrogel called nucleoporin. The nucleoporin facilitate the rapid passage of macromolecules with high selectivity (＜ 0.1% of all proteins are allowed). The dense nucleoporin network rejects large molecules more than 5 nm by its network pore size, however, some molecules overcome this entropic barrier if there is a binding affinity between nucleoporin and transporting molecules. The hydrogels for recognition and selective permeation (GRASP) was engineered based on two main factors involve in selective separation (entropic repulsion and binding affinity). To promote selective permeation of target molecules dominantly, the GRASP having diverse affinities with transporting molecules were designed. The GRASP successfully rejected non-specific polyclonal antibodies, whereas specifically allowed monoclonal antibodies. The rationally designed nucleoporin-inspired hydrogels showed high potential of tuning permeability and selectivity of biomolecules for separation technologies. |
| 저자 | 양윤정1, Bradley D. Olsen2 |
| 소속 | 1인하대, 2Department of Chemical Engineering |
| 키워드 | 생물화학공학 |
| 원문파일 | 초록 보기 |
