| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Silk Fibroin Scaffolds as a Transporter to Deliver Demineralized Bone Particles for Bone Defect Treatment |
| 초록 |
Silk fibroin has been widely used in tissue engineering due to its biocompatibility and biodegradability. Demineralized bone particle (DBP) is well-known as an inducer of osteogenesis. Herein, we have designed silk fibroin scaffolds loaded with DBP for bone defect treatment. Structural properties were performed using SEM. And cell proliferation activity and osteogenesis were evaluated by MTT and ALP assay. Various mRNA from scaffolds were also collected and studied. Furthermore, histological staining demonstrated enhancement in the nucleation sites of bone marrow mesenchymal stem cells. Collectively, the enhancement in mechanical properties result in formation of bone matrix and cell growth through establishment of structural connectivity of the fabricated silk fibroin-DBP scaffolds. This research was supported by Bio-industry Technology Development Program (112007-05-3-SB010), Technology Commercialization Support Program (814005-03-1-HD020) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
강길선, 송정은, Nirmalya Tripathy, 김은영, 국현
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| 소속 |
전북대 |
| 키워드 |
Bone marrow mesenshymal stem cell; Demineralized bone particle (DBP); Osteogenic differentiation; Osteogenesis
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| E-Mail |
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