| 초록 |
Silk is a potential material for biomedical applications. To increase osteoconductivity and osteoinductivity, we modified the mechanical property and osteoconductivity of silk with β-TCP. We checked the physical and chemical characterizations of silk /β-TCP scaffolds using SEM, compressive strength, and FTIR, etc. Also, osteogenic differentiation of rabbit bone marrow mesenchymal stem cells (rBMSCs) cultured in scaffold was evaluated by using alkaline phosphatase, MTT, RT-PCR, SEM. These results showed that 75/25 scaffold increased cell proliferation and differentiation of rBMSC in vitro for 1 to 4 weeks. From these results, it could be suggested that silk25/β-TCP75 scaffold is applied to one of useful biomaterials in terms of bone regeneration. This research was supported by Bio-industry Technology Development Program (112007-05-3-SB010), Technology Commercialization Support Program (814005-03-1-HD020), Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea. |
