| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of the concentration of Sodium alginate on the BSA Release from BSA/PLGA microspheres |
| 초록 |
We developed the BSA loaded PLGA microspheres using a sodium alginate and water-in-oil-water (W/O/W) solvent evaporation method for sustaining release of BSA and recognized the release behavior according to sodium alginate concentration. We chracterised the surface and the cross-section morphology of prepared PLGA microspheres by the SEM and behavior of BSA release from microspheres for 45 days by BCA assay method. After 45 days, the molecular weight change of PLGA was measured by GPC. The surface of microspheres appeared sphere shape and had may pores. According to sodium alginate concentration increasing, the size of microspheres increased and release rate of BSA from microspheres decreased. These results show that the change of sodium alginate concentration can control the release behaviors. |
| 저자 |
박종학, 안식일, 이준희, 김윤태, 김대성, 김원, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
BSA; PLGA; microspheres; sodium alginate; GPC
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| E-Mail |
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