| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
In vivo imaging and regression of high-risk plaques with photoactivatable nanoagents |
| 초록 |
A novel scavenger receptor-A-targeted photoactivatable theranostic nanoagents were developed by the chemical reaction of dextran sulfate with chlorin e6. The theranostic nanogents were taken up by the activated macrophages and induced cell death after light irradiation. After the injection of theranostic nanoagents in apoE knockout mice with FITC-dextran angiography, carotid images done by intravital fluorescence microscope showed clear detection of the plaque macrophages. After carotid IVFM imaging, light irradiation was performed with a diode laser . At 1 and 4 weeks after laser irradiation, a serial IVFM imaging showed a significant decrease of fluorescence signals at plaque macrophages in vivo compared to the base line. Also, histological analysis demonstrated the reduction of macrophages and increase of collagen formation in the plaque, implying the plaque stabilization. |
| 저자 |
박경순1, 송준우2, 이민우3, 김현정2, 오왕렬4, 유홍기3, 김진원2
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| 소속 |
1중앙대, 2고려대, 3한양대, 4한국과학기술원 |
| 키워드 |
High-risk plaque; macrophage; photoactivatable nanoagents; Photodynamic therapy
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| E-Mail |
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