| 학회 |
한국화학공학회 |
| 학술대회 |
2005년 봄 (04/22 ~ 04/23, 여수대학교) |
| 권호 |
11권 1호, p.284 |
| 발표분야 |
분리기술 |
| 제목 |
The formation of protein-loaded microparticles by supercritical fluid processing method |
| 초록 |
In this study, we use supercritical CO2 as a processing medium for the fabrication of poly (lactide-co-gycolide) (PLGA) microparticles that encapsulate a protein material. Lysozyme is used as the model protein. We demonstrated that this polymer and a dry powder of a protein can be mixed under supercritical carbon dioxide conditions and that the protein component retains its biologycal activity. In this experiment, we progress the work to demostrate that the plasticized polymer and dry powder protein mixture can be sprayed to form solid polymer that encapsulate the protein. The methodology is based on the technique of the particle generation from supercritical suspension (PGSS). Particle size range is between 30 and 300 ㎛ after spraying. Particles were irregularly shaped with some pores. Lysozyme was encapsulated in the polymer without significant loss of enzymatic activity. |
| 저자 |
정헌섭1, 이한호2, 이창하3, 임종성4, 이윤우2
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| 소속 |
1한국과학기술(연), 2서울대, 3연세대, 4서강대 |
| 키워드 |
Supercritical CO2; Poly (lactide-co-gycolide); PGSS; Plasticization; Encapsulation
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| E-Mail |
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| 원문파일 |
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