| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
International Symposium on Advanced Biopolymers (의료용 고분자 부문위원회, 영어발표) |
| 제목 |
Smart Nanofibers for Biomedical Applications |
| 초록 |
We are studying smart nanofibers for biomedical application such as cell capture and release aiming at cell container and cancer therapy. About the use for anticancer, self-heating and temperature-responsive nanofiber incorporated magnetic nanoparticles was developed because of their self-heating property by applying alternative magnetic field (AMF). Polymer composite nanofiber composed of poly (NIPAAm-co-HMAAm), MNPs and Doxorubicin were prepared by electrospinning followed by the cross-linking reaction. To test both thermotherapy and chemotherapy effects of composite nanofiber, the cytotoxicity to human melanoma cell line COLO 679 cells were evaluated. In case of DOX/MNP-nanofiber, cell viability decreased to 70% by AMF application. Although the thermotherapy effect itself showed a minor anticancer effect for a short duration AMF application, DOX released from the nanofibers induced the apoptosis of cancer cells due to a synergistic effect in combination with thermotherapy. |
| 저자 |
Mitsuhiro Ebara1, Koichiro Uto2, Young- Jin Kim1, Takao Aoyagi1
|
| 소속 |
1International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS) 1-1, 2: International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS) 1-1 |
| 키워드 |
thermoresponsive; nanofiber; magnetic nanoparticle
|
| E-Mail |
|
