| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터) |
| 권호 |
15권 1호 |
| 발표분야 |
고분자 |
| 제목 |
Design of photosensitizer-conjugated pH-sensitive polymeric nanoparticles for photodynamic therapy |
| 초록 |
To achieve an effective tumor-targeted drug delivery system for photodynamic therapy, ligand-medicated nanoparticles as stable formations of hydrophobic photosensitizer were designed. Novel folic acid/photosensitizer-conjugated copolymers composed of PEG and PBLA with the potential capacity for serving as pH-responsive drug release reservoirs were synthesized. The photosensitizer-loaded copolymeric nanoparticles were prepared by micelle formation. The composition of copolymers and properties of self assembled nanoparticles were characterized. The release profiles of photosensitizer were strongly pH-dependent and influenced by the amount of photosensitizer. |
| 저자 |
자오린린, 김소연
|
| 소속 |
충남대 |
| 키워드 |
photodynamic therapy; nanoparticle; photosensitizer; tumor targeting
|
| E-Mail |
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