| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 가을 (11/02 ~ 11/04, 경원대학교) |
| 권호 |
15권 2호 |
| 발표분야 |
생물공학 |
| 제목 |
Tumor Penetrating Peptide Enhances Tumor Uptake of Co-administered Monoclonal Antibody |
| 초록 |
A tumor-penetrating peptide, CRGDKGPDC (iRGD) was reported to enhance vascular permeability and tumor tissue penetration of co-administered drugs in a αvβ3 specific and neuropilin-1 dependent manner. We investigated the effect of intravenously co-administered iRGD on the enhancement of tumor vascular permeability to In-111 labeled B3, IgG1k mAb directed against Ley antigen. We used A431 tumor-bearing nude mice as a model. A431 cell expresses Ley, but not αvβ3 and neuropilin-1on the cell surface. The results of the study indicate that the iRGD coinjection increased the extravasation of In-111 B3 into interstitial space of A431 tumor by 29~31%. |
| 저자 |
이상명1, Zhengsheng Yao2, Insook Kim2, Sung Jin Lee2, Jae Ho Lee2, Yujian Zhang2, Peter L. Choyke2, Ira Pastan2, Chang H. Paik2
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| 소속 |
1강원대, 2National Institutes of Health |
| 키워드 |
Tumor penetrating peptide; monoclonal antibody; radiolabeling
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| E-Mail |
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