| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dual BMPs-immobilized Polydioxanone Porous Beads for the Accelerated Bone Regeneration |
| 초록 |
Sufficient reconstruction of bony defect caused by fraction, tumor resection, and skeletal deformities is often essential. Recently, autologous transplantation of cortical and cancellous bones have been considered as a gold standard for the effective bone regeneration, however, donor site morbidity and limited availability of donor materials are still remained as significant challenges in clinical field. To overcome these limitations, we prepared porous polydioxanone (PDO)/Pluronic F127 beads, and the dual BMPs (BMP-2 & BMP-7) which can induce osteoblast differentiation in a variety of cell types and stimulate bone regeneration were immobilized onto the pore surfaces of the beads via heparin binding. The release profiles of BMPs immobilized on the porous beads and their bone regeneration behavior were investigated by histological and micro-CT observations using rat model (skull defect). |
| 저자 |
김태호1, 강준구1, 안단비1, 오세행1, 전소영2, 이진호1
|
| 소속 |
1한남대, 2경북대병원 국제재생의학(연) |
| 키워드 |
Dual BMPs; Porous Beads; Bone Regeneration
|
| E-Mail |
|
