| 학회 |
한국재료학회 |
| 학술대회 |
2013년 가을 (11/06 ~ 11/08, 제주롯데호텔) |
| 권호 |
19권 2호 |
| 발표분야 |
B. 나노 재료(Nano Materials) |
| 제목 |
Europium-doped gadolinium sulfide nanoprobes for magnetic resornance and photoluminescence imaging |
| 초록 |
Europium-doped gadolinium sulfide (GdS:Eu3+) opto-magnetic nanoparticles (NPs) were prepared by a facile sonochemical synthesis method. Due to their photoluminescence and strong paramagnetic properties, these NPs were used as an in vitro cell imaging and in vivo T1-weighted MR imaging agent. The GdS:Eu3+ NPs have a prominent longitudinal (r1) relaxivity value, which is a critical parameter for T1- weighted MR imaging. We showed their strong positive contrast effect to blood vessels and organs of mice and blood half-life and biodistribution including clearance from organs. Furthermore, we showed confocal images of breast cancer cells containing GdS:Eu3+ NPs to evaluate as a photoluminescence probe. Dual-mode imaging capability obtained from the GdS:Eu3+ NPs will allow target-oriented cellular imaging as well as the resulting disease-specific MR imaging. |
| 저자 |
Hye Mi Jang1, Jongjin Jung1, Mi Ae Kim1, Jee-Hyun Cho2, Seung Jae Lee1, Ja Young Park1, Joung Guy Park1
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| 소속 |
1Korea Research Institute of Chemical Technology, 2Korea Basic Science Institute |
| 키워드 |
Europium-doped GdS nanoparticles; Positive contrast agent; MRI; Fluorescence
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| E-Mail |
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