| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 |
18권 1호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Boronic acid and catechol conjugated polymer for having pH sensitive polymer with BODIPY use as cancer cell detection |
| 초록 |
This paper is reports the development of pH responsive polymeric nanoplatforms having pH responsive boronate ester with reduced graphene oxide(rGO). The facile conjugation between BODIPY/Boronic acid conjugated PEG-g-poly(DMA-co-NIPAAm) and catechol conjugated poly(DMA-co-NIPAAm) with rGO was confirmed by 1H NMR, UV-vis and fluorescence spectroscopy. This nanoplatforms is confocal images of the prepared nanoplatforms against MDA-MB 231 breast cancer cells confirm the intense green fluorescence at low and high pH values but no fluorescence signal under physiological pH condition enabling the nanoplatforms as a novel fluorescence probe. The nanoplatforms also revealed outstanding cell viability. Therefore, the developed nanoplatforms are novel candidate for a fluorescent probe to effectively detect tumor cells. |
| 저자 |
이소영, 신춘임, 김성한, 박수정, 강은비, 박성영
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| 소속 |
한국교통대 |
| 키워드 |
BODIPY; Boronic acid; Catechol; pH sensitive; Cell imaging.
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| E-Mail |
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