| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
NONOATES-POLYETHYLENIMINE HYDROGEL FOR CONTROLLED NITRIC OXIDE RELEASE AND CELL PROLIFERATION MODULATION |
| 초록 |
In recent years numerous research activities have been devoted towards the controlled release of nitric oxide (NO) due to its potential as restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, and the apoptosis of vascular endothelial cells. This work has demonstrated the development of novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI) and diazeniumdiolates (NONOates). NO-conjugated gel system, F127-BPEI-NONOates reduced initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127. |
| 저자 |
김지훈1, 이양기2, Kaushik Singha1, 김현우1, 신재호3, 조성봉4, 한동근2, 김원종1
|
| 소속 |
1포항공과대, 2한국과학기술(연), 3광운대, 4미시시피대 |
| 키워드 |
Polyethylenimie; NONOates; Restenosis; Hydrogel; smooth muscle cell; endothelial cell
|
| E-Mail |
|
