| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Effect of PEG-based block copolymer for controlled drug release |
| 초록 |
Our hypothesis is thatdrug release from biodegradable polymers can be controlled by blending hydrophilic poly(ethyleneglycol) (PEG)-base polymer as additives and also by regulating molecular weight and blending ratio of each polymers. Particularly, we focused on F127 and F68 consisted in PEG-polypropylene glycol (PPG)-PEG among PEG-based copolymers because of FDA approval and application in controlled drug delivery. The effect of PEG-based block copolymer as additives was investigated in controlling drug release from sirolimus (SRL)-loaded biodegradable polymer. The solution of SRL-loaded polymer was coated on stainless steel (SS) by ultrasonic spray. The coating surface of SS was characterized by SEM and their drug-release kinetics were analyzed by HPLC. |
| 저자 |
김진향, 박귀덕, 최지연, 한동근
|
| 소속 |
한국과학기술(연) |
| 키워드 |
Sirolimus; biodegradable polymers; additives; stent
|
| E-Mail |
|
