| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dextran coated Gold nanorods for photothermal ablation of macrophages |
| 초록 |
We synthesized dextran-coated gold nanorods (DEX_GNRs) as a nanoprobe to permit the targeting of macrophgae cells. In this study, we synthesized thiolated dextran and conjugated with gold nanorods (GNRs) using self assembly reaction. We can find both synthesis of thiolated dextran through FT-IR and Ellman’s reagent and then synthesis of GNRs through TEM and UV-VIS. We demonstrate that the Au concentration of dextran coated GNPs taken up by macrophage cells can be determined using ICP-AES. We performed a cell viability test to examined the cellular cytotoxicity of dextran coated GNRs using RAW264.7 (macrophage cell line). We exposed to NIR laser in incubated RAW 264.7 cells with DEX_GNRs to estimate the photothermal effects. According to this experiment, we formulated DEX_GNRs exhibited non-cytotoxicity, which showed the highly efficient photothermal ablation ability in macrophage cells under NIR irradiation. |
| 저자 |
최라윤, 함승주, 최지혜, 임은경, 서진석, 허용민
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| 소속 |
연세대 |
| 키워드 |
gold nanorod; dextran; macrophage; photothermal
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| E-Mail |
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