| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Specific targeted optical image nanoprobe of αvβ3 integrins as receptors for tumor |
| 초록 |
We studied a new class of targeted imaging agents employing the PEGylated gold nanorods conjugated with cRGD for αvβ3 integrins specific tumor-cell targeting. The gold nanorods having an optical resonance peak in the NIR region were synthesized by the seed-mediated growth method. Then CTAB bilayer was replaced with heterobifunctional polyethyleneglycol (COOH-PEG-SH) as a biocompatible stabilizer on gold nanorods. Further, the carboxylated gold nanorods can be easily functionalized with cRGD to produce cRGD conjugated gold nanorods by using EDC-NHS chemistry. In order to assess the potential of the cRGD-PGNRs to serve as targeted imaging agents, we investigated their optical properties, biocompatibility, colloidal stability and affinity for tumor cells as well as in vitro/vivo. |
| 저자 |
최지혜, 함승주, 허용민, 서진석, 김은정, 최라윤, 박요셉
|
| 소속 |
연세대 |
| 키워드 |
gold nanorod; imaging; cRGD; tumor
|
| E-Mail |
|
