| 초록 |
Cancer remains one of the world's most devastating diseases, with more than 10 million new cases every year. With the ongoing efforts in cancer research, mortality from cancer has indeed decreased in the past two years owing to better understanding of tumor biology and improved diagnostic devices and treatments. This presentation will discuss the current technology to improve anti-cancer treatment approaches. The enhancement could be achieved via 1) targeted drug delivery and 2) targeted capturing of specific cells. For the development of nanocarriers for targeted drug delivery, we performed a fundamental study on the biological interactions of synthetic polymers, which revealed that polycationic polymers of linear and dendritic architecture induce membrane permeabilization (nanoscale hole formation) in living cells. Polyamidonamine (PAMAM) dendrimers were further studied to be used as a targeted delivery vector. The targeted dendritic nanodevices provide the multivalent interaction with a receptor protein target as observed in unprecedented quantitative and systematic evidence. These data support the hypothesis that multivalency, rather than an enhanced rate of endocytosis, is the key factor resulting in the improved biological targeting by the drug delivery platform, thus providing a design guide for future receptor targeting agents. A strategy to capture/separate specific target cells based on cell rolling will be also discussed, focusing on the development of controlled covalent immobilization methods of proteins and its translation into device technology. This approach is essential for mimicking relevant complexities of the in vivo rolling response and for future development of devices for isolating specific cell types such as circulating tumor cells with metastasis potential. |
