| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation |
| 초록 |
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity. |
| 저자 |
홍철암1, 남윤성2
|
| 소속 |
1KAIST, 2한국과학기술원 |
| 키워드 |
small interfering (siRNA); Hydrogels; Gene silencing; siRNA structure
|
| E-Mail |
|
