| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.640 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Release Behavior of BSA Loaded MPEG-PLGA Diblock Copolymer wafers as Implantable Protein Carriers |
| 초록 | Biodegradable polymers find increasing applications in the pharmaceutical industry as matrices for drug delivery system.1 Poly(lactide-co-glycolide) (PLGA) as one of the most commercial biodegradable polymers has been used as controlled drug delivery matrix of nano-, micro-particles, implantation, and hydrogels. The introduction of poly(ethylene glycol) (PEG) in PLGA polymers to deliver more effectively drug could exhibit various advantages such as controlled drug release, improved biocompatibility, non-toxicity, and protein resistivity.2 In this study, we synthesized MPEG-PLGA diblock copolymers using ring-opening polymerization of L-lactide and glycolide with carbitol and PEG as an initiator in presence of Sn(Oct)2. (Table 1) After uniform mixing of diblock copolymers and 1% albumin bovine-fluorescein isothiocyanate (BSA-FITC) as a model protein with a freeze miller, the release profiles of BSA-FITC in PBS showed fast initial burst as the molecular weights of MPEG increased. Also the release behavior was controlled by the addition of additives such as PEG, PVP, Carbopol, and small intestinal submucosa (SIS). In conclusion, the wafer formed by MPEG-PLGA diblock copolymers could posses a promising foundation for protein delivery. Reference 1. B. Bittner, C. Witt, K. Mader, and T. Kissel, Journal of Controlled Release, 60, 297 (1999). 2. W. Jiang and S. P. Schwendeman, Pharmaceutical Research, 18, 878 (2001). |
| 저자 | 서광수1, 이창신2, 현훈1, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2한남대, 3한국화학(연) |
| 키워드 | MPEG-PLGA; protein; wafer |
