| 초록 |
Thermally sensitive and biodegradable hydrogels based on Pluronics tri-block copolymer were prepared by using a photo-polymerization method. Two terminal hydroxyl groups in Pluronic F-127 were acrylated to form a photo-crosslinkable Pluronic macromer. Photo-crosslinked Pluronic hydrogels by UV radiation showed gradually decreased swelling ratio with increasing temperature and thermally responsive change in the swelling ratio when cycling the temperature between 10℃ and 37℃. These hydrogels also exhibited degradation behaviors due to the cleavage of ester linkage in the acrylated Pluronic terminal end. When lysozyme, a model protein drug, was loaded in the hydrogels, bi-phasic protein release profiles were attained. A burst-free and rapid controlled release rate was observed up to a one week period followed with a much slower sustained release rate thereafter. The release rates could be controlled by varying the amount of Pluronic macromer for photo-polymerization. |
