| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Preparation of intelligent drug nanoparticles by comminution and crosslinking |
| 초록 |
Stable drug nanoparticles can be conveniently prepared by comminution in the presence of polymeric stabilizers. In this study, the comminution method was further developed to prepare polymeric empty cages and surface modified drug nanocrystals. Drug nanoparticles were first prepared to have chitosan chains on their surface. Then, the absorbed chitosan was crosslinked by ionic gelation with tripolyphosphate anions (TPP). Empty cages were prepared by removing drug nanocrystal cores within the crosslinked chitosan. Empty cages can be loaded with different materials. In another approach, folic acid as a ligand for targeting cell membrane was conjugated with chitosan. |
| 저자 |
김수정, 이종휘
|
| 소속 |
중앙대 |
| 키워드 |
nanoparticle; polymeric stabilizers; chitosan; folic acid
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| E-Mail |
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