| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Decellularized Heart ECM Hydrogel by Supercritical Carbon Dioxide for Improving the Effect of Angiogenesis |
| 초록 |
Decellularization is a removal of cells from tissues and organs, resulting in remaining extracellular matrix components. To preserve useful ECM components and angiogenic cytokines in decellularized extracellular matrix (dECM), decellularization process needs to selectively remove target molecules such as cell membrane and nucleic acid except various ECM proteins and cytokines. Supercritical CO2 (scCO2) is the most common candidate gas because of its low toxicity, low flammability and environmental acceptability. In this study, rat heart tissues were decellularized with scCO2-EtOH and heart dECM was solubilized into acetic acid and formed heart ECM derived-hydrogel. To estimate angiogenesis, heart dECM(HdECM) hydrogel was injected in rat subcutaneous layers and explanted after 3 days. Finally, we suggest that scCO₂-EtOH decellularized tissue could be promising materials for tissue repair and microenvironment around the cells in tissue engineering. |
| 저자 |
서유진1, 정영미2
|
| 소속 |
1KIST / KU-KIST Graduate School of Converging Science and Technology, 2Korea Univ. |
| 키워드 |
Decellularization; supercrical carbon dioxide; ECM hydrogel
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| E-Mail |
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