| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The formation and characterization of retinol-chitosan nanocomplexs |
| 초록 | Chitosan is a natural polymer derived from chitin by deacetylation. Since chitosan is regarded as biocompatible, biodegradable, and non-toxic, it is interesting biomaterials because of its ability as a drug carrying materials and ease of modification[1]. Furthermore, chitosan has been reported to enhance drug delivery across the nasal or mucosal layer without damage[2,3]. Despite of its superiority as a biomaterials, chitosan is not fully soluble in water and then soluble in acidic solution. Aqueous solubility of chitosan only in acidic solution limits its application to bioactive agents such as gene delivery carriers, peptide carriers, and drug carriers. Nah and Jang (2002) developed water-soluble chitosan with low molecular weight and free-amine group[4]. Water-soluble chitosan (WSC) is ease of soluble in neutral aqueous solution. Its advantage is ease of modification, useful as a gene or peptide drug carriers, and drug carriers [5]. Retinol and its derivatives are extensively used in the pharmaceutical and cosmetic area. Especially, retinoids are recognized to important for modern therapy of dermatological treatment of wrinkled skin [6]. Of the retinoids, retinol and retinyl palmitate are thought to induce thickening of the epidermis and to be effective for treatment of skin diseases. These functional substances, however, are known to be unstable if exposed to light or heat.. Although retinol and retinyl palmitate are less toxic than retinoic acid (which, due to its irritative properties, is acceptable only for therapeutic treatment) the ultraviolet effect on these compounds makes their use in dermatology more difficult. For this study, we prepared retinol-encapsulated chitosan nanoparticles. Preparation and their physicochemical properties of chitosan nanoparticles were investigated using various analytical equipments such as Transmission Electron Microscope(TEM), Dynamic Light Scattering(DLS). This work was supported by National Research Laboratory (NRL) project of the Ministry of Science and Technology in Korea. 참고문헌 1. Hirano, S., 1999. Chitin and chitosan as novel biotechnological materials, Polym. Int. 48, 732-734. 2. Fernandez-Urrusuno, R., Calvo, P., Remunan-Lopez, C., Vila-Jato, J.L., Alonso, M.J., 1999. Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm. Res. 16, 1576-1581 3. Kotez, A.F., de Leeuw, B.J., Lueben, H.L., deBoer, A.G., Verhoef, J.C., Junginger, H.E., 1997. Chitosan for enhanced delivery of therapeutic peptides across intestinal epithelia: In vitro evaluation in Caco-2 cell monolayers, Int. J. Pharm. 159, 243-253 4. Nah, J.W., Jang, M.K., 2002. Spectroscopic characterization and preparation of low molecular, water-soluble chitosan with free-amine group by novel method, J. Polym. Sci. Part A: Polym Chem. 40, 3796-3803. 5. Lee, M., Nah, J.W., Kwon, Y., Koh, J.J., Ko, K.S., Kim, S.W., 2001. Water-soluble and low molecular weight chitosan-based plasmid DNA delivery, Pharm Res. 18, 427-431 6. Guénin, E.P., Zatz, J.L., 1995. Skin permeation of retinyl palmitate from vescicles. J. Soc. Cosmet. Chem. 46, 261–270. |
| 저자 | 김동곤1, 정영일1, 장미경1, 권중근2, 박준규1, 나재운1 |
| 소속 | 1순천대, 2조선이공대 |
| 키워드 | : Water-soluble chitosan; retinol; polyion complex; nanoparticles; anticancer drug |
