| 학회 |
한국재료학회 |
| 학술대회 |
2015년 가을 (11/25 ~ 11/27, 부산 해운대그랜드호텔) |
| 권호 |
21권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 |
| 제목 |
Soy-Gelatin Based Electroactive and Multi-interactive Hydrogel for Tissue Engineering |
| 초록 |
Understanding how materials fundamentally affect cellular functions is essential for many tissue engineering applications together with the ability to synthesize biomaterials that can mimic elements of the native cell or mimic extracellular matrix interactions. Recently “smart” hydrogels or stimuli-responsive hydrogels that can change their properties in response to environmental stimuli has been studied as platforms for developing tissues for numerous applications. We examined the effects of inter- and intra-cellular ionic balance by applying weak electrical pulses on different cell types (L929, MC3T3-E1, rBMSC) and assessed the effects on their migration, proliferation and differentiation. The effect of the hydrogel from isolated soy protein and gelatin on the cultured cells in terms of morphology, surface markers, protein and gene expressions and potential extracellular matrix production was also analyzed. By employing the appropriate combination of stimuli and hydrogel composition and architecture, cell behavior such as adhesion, migration, proliferation, and differentiation can be controlled in real time. This three-dimensional control in cell behavior can help create programmable cell niches that can be useful for fundamental cell studies. |
| 저자 |
Byong-Taek Lee1, Reiza Ventura2, Celine Abueva3
|
| 소속 |
1Institute of Tissue Regeneration, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Electroactive; Smart hydrogel; Soya; Stem Cell; Tissue engineering
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| E-Mail |
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