| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
ROS sensitive PPADT-PEG Block Copolymers for Drug Delivery |
| 초록 |
To deliver siRNA to the reactive oxygen species (ROS)-rich inflamed intestinal tissue, poly-(1,4-phenyleneacetone dimethylene thioketal) (PPADT) has been reported to protect siRNA from the low pH of the gastrointestinal tract and to ensure its targeted delivery (Nature Materials, (2010) 9, 923-928). In this poster, the molecular mass and polydispersity of PPADT can be fine-tuned by the ratio of p-toluenesulphonic acid (PTSA; catalyst) to monomers and the ratio of monomers with respective to each other (i.e. DMP:BDT). PPADT of different molecular masses were subsequent conjugated with PEGs to prepared PPADT-PEG block copolymers with various hydrophobic to hydrophilic ratios, which may affect the degradation behaviors of the PPADT-PEG micelles. |
| 저자 |
Geok Leng Seah1, 김지선2, 남윤성2
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| 소속 |
1Korea Advanced Institute of Science and Technology, 2한국과학기술원 |
| 키워드 |
reactive oxygen species (ROS); poly(1; 4-phenyleneacetone dimethylene thioketal) (PPADT); block copolymers; drug delivery; polymeric micelles
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| E-Mail |
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