| 초록 |
Cisplatin (cis-[PtCl2(NH3)2]) is one of the most widely used anticancer agents because it plays a important role in the cure of various cancers such as testicular, ovarian, head and neck cancer, as well as several others. However, cisplatin is vulnerable to be attacked by plasma proteins such as serum albumin inducing many side effects to the normal tissue and leading to less therapeutic efficacy. To improve these problems, various Pt(IV) based prodrugs have been emerged. They have less potency and toxicity before they are reduced to their corresponding Pt(II) derivatives by reductive environment inside cells. Two additional coordination sites on prodrug also offer great synthetic flexibility. In our system, we use these modified prodrugs to conjugate with nano-sized mesoporous silica nanoparticles in order to cancer specific delivery via enhanced permeability and retention (EPR) effect. Herein, high selectivity, safety, and stimuli-responsive drug delivery systems will be discussed. |
