| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
(생물공학) 생리활성 이차대사산물 생산 최신동향 |
| 제목 |
Microbial Production of Natural and Non-natural Products: Flavonoids and Anthraquinone |
| 초록 |
Development of microbial cell factories via metabolic engineering, protein engineering and synthetic biology has revolutionized the maximum use of microbial systems for biosynthesis and modification of valuable flavonoids and anthraquinone. From a single enzyme expression to complex metabolic pathway, it has been possible to manipulate strains such as Escherichia coli and Streptomyces for target based modification of compounds to industrial level in laboratory. Biotransformation, a biotechnological approach can be applied to structurally modify and generate library of natural products such as flavonoid and anthraquinone derivatives. Basically E. coli has been engineered by expressing secondary metabolites post modifying enzymes such as glycosyltransferases (GTs) and O-methyltransferases (OMTs) in particular to generate the natural and non-natural flavonol and anthaquinone derivatives. |
| 저자 |
Jae Kyung Sohng |
| 소속 |
SunMoon Univ. |
| 키워드 |
Flavonoids; pathway engineering; metabolic engineering; post-modifications; anthraquinones; anti-cancer agents; glycosyltransferase
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| E-Mail |
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