| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
pH-Responsive and Biocompatible Multilayer Thin Films Based on Cooperative Zipping Effect of Hyaluronic Acid for Controlled Release |
| 초록 |
We demonstrate biocompatible and therapeutical multilayer thin films composed of [polyethylene glycolpoly(lactic-co-glycolic acid) block copolymer micelles (PEG-PLGA BCMs) - hyaluronic acid (HA)] blend layers and linear polyethylene imine (LPEI) layers. Mutlilayer thin films are sequentially deposited on substrates using the electrostatic interaction between HA and LPEI by the dip-assisted layer-by-layer deposition method. Biodegradable, non-charged PEG-PLGA BCMs carrying water insoluble target drugs are physically entrapped within the interconnected network of HA matrix layers. The amount of PEG-PLGA BCMs within the multilayer films were characterized by ellipsometry, AFM, SEM and fluorescent microscopy. Prepared (LPEI/PEG-PLGA BCMs - HA)n multilayer thin films show the controlled release behavior depending on the film compositions at biologically compatible condition (pH 7.4). |
| 저자 |
박새봄, 서진화, 차국헌
|
| 소속 |
서울대 |
| 키워드 |
biocompatible; polymer micelle
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| E-Mail |
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