| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.332 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation of Polyaspartamide as Drug Carriers |
| 초록 | Several poly(amino acid) derivatives have been intensively investigated as a drug carrier for drug delivery system (DDS). Particularly, polysuccinimide (PSI) is one of the most promising drug carriers since it possess suitable physico-chemical characteristics for development of macromolecular prodrugs, due to biocompatibility, biodegradability, ease synthesis, low cost and easy functionalization. In this study, we deal with the synthesis of polyaspartamide having various functional groups such as PEG, 1-hexadecylamine (C16) and phospholipid via ring opening of PSI. PSI was synthesized by polycondensation polymerization of aspartic acid. The ring of PSI remained in PEG functionalized polyaspartamide was also modified by the successive reaction of C16 and phospholipid with amine end group. All materials were characterized by 1H-NMR and IR. In addition, the formation of nanoparticle micelle as drug carrier were also examined. Micelle size was measured by ELS and AFM. The functionalized polyaspartamide formed nanoparticle micelle of which size ranged from 90 to 300 nm. In conclusions, we confirmed that polyaspartamide functionalized with PEG, C16 and phospholipid might be the possibility as drug carriers. Acknowledgment : This work was supported by KMOCIE (10011394) |
| 저자 | 임낙현1, 서광수1, 김문석2, 이해방2, 강길선1, 조선행2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | polyaspartamide; nanoparticle; drug carrier |
