| 초록 |
The hierarchical nanoarchitectures have been of great interest for surface-enhanced Raman scattering (SERS)-based biosensing and bioimaging. Since 2010, we have developed clustering strategies of isotropic and anisotropic metallic nanoparticles (MNPs) and prepared the MNP cluster-embedded hierarchical nanostructures via electrohydrodynamic (EHD) jetting for highly sensitive detection of biological markers as well as cells. We have systematically studied their structure-property relationship based on (1) clustering of isotropic and anisotropic MNPs, (2) formation of hierarchical structures, and (3) multiplexing. Furthermore, excellent multiplexing capability using SERS and fluorescence-based dual nanoprobes was obtained with negligible background and non-specific binding. Conclusively, these controlled hierarchical nanostructures open a new avenue for photonics-based multiplexing system in diagnostics. |
