| 학회 | 한국화학공학회 |
| 학술대회 | 2004년 봄 (04/23 ~ 04/24, 공주대학교) |
| 권호 | 10권 1호, p.451 |
| 발표분야 | 생물화공 |
| 제목 | The production of the next generation anti-cancer drug Epothilone using Myxobacterium Sorangium cellulosum |
| 초록 | Epothilones are secondary metabolites that are naturally produced by the myxobacterium Sorangium cellulosum. They are potent inhibitors of microtubule depolymerization, with a mechanism of action similar to that of the anti-cancer drug Taxol. However, their efficacy against Taxol-resistant tumor cell lines and higher water solubility potentially position epothilones to be the next generation of chemotherapeutic compounds for the treatment of cancer. Epothilone A and B are the major products of the natural host. It has been known that malonyl-CoA and methylmalonyl-CoA are source for production of Epothilone A and Epothilone B respectively. In this study, We designed medium compostion for selective production of Eopithilone B because Epothilone B is more effective anti-tumor agent than Epothilone A. |
| 저자 | 박상우, 최수형, 심상준 |
| 소속 | 성균관대 |
| 키워드 | Epothilone |
| 원문파일 | 초록 보기 |
