| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.366 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | pH-responsive polymeric micelle for cancer drug delivery : amphiphilic diblock copolymer with N-acetyl histidine |
| 초록 | Micelles have been received attention in drug delivery system, due to their drug loading capacity in the interior site and being able to keep away from RES(reticuloendothelial system). In recent years there is many research about various stimuli-sensitive micelles for adequate drug release in desired region. In this study pH-sensitive polymeric micelle was improved for cancer therapy. Because pH 6.0~7.2 is maintained at exterior environment of tumor cell, micelles must be unstable at pH 6.0~7.2 and stable at pH 7.4. Then drugs are accumulated in tumor cell due to the collapsing of micelle. Methoxy poly(ethylene glycol)-poly(ε-caprolactone-co-D,L-lactide) diblock copolymer was used for polymeric micelle and N-acetyl histidine was introduced to diblock copolymer. |
| 저자 | 김민상, 이두성 |
| 소속 | 성균관대 |
| 키워드 | pH-sensitive; polymeric micelle; N-acetyl histidine |
