| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.311 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of BCNU from the wafer in vivo against rat malignant brain tumors |
| 초록 | Carmustine (BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea) is an alkylating antineoplastics agent for malignant brain tumor. Institutial chemotherapy using biodegradable polymers as drug carriers is one of the most effective chemotherapies to control the release of drug during treatment. In this study, the effect of the BCNU incorporated into wafer implanted adjacent to the 9L gliosarcoma was assessed in the sucutaneous models. In the sucutaneous experiment, the tumor cell was implanted in the sbcutatis of the back of rats and subsequently treated with BCNU delievered in controlled release polymers inserted adjacent to the tumor. The interstitial release of BCNU adjacent to the tumor in the back resulted in a significant tumor growth delay as compared with non-treated models. The localized, controlled delivery of chemotherapeatic agent in the subcutaneous tissues via polymeric carriers may be more effective than non-treated models. Moreover, we showed the feasibility for clinical application as compared with different dose. Acknowledgment: This work was supported by KMOCIE(B49-990-5411-05-1-3) |
| 저자 | 안태군1, 이진수2, 신필경*3, 성하수**4, 정제교***, 강길선, 이해방** |
| 소속 | 1전북대, 2*부경대, 3**한국화학(연), 4***삼천당제약 중앙(연) |
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