| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.361 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and characterization of Aceclofenac using self micro emulsifying drug delivery systems (SMEDDS) |
| 초록 | Aceclofenac is 2-[(2,6-Dichlorophenyl) amino] benzeneacetic acid carboxymethyl ester and is used as anti-inflammatory drug(NSAIDs).1,2 Aceclofenac inhibits the cycle-oxygenase enzyme system and hence reduces the biosynthesis of prostaglandins.3 Because aceclofenac is lipophilic material, it is easily dissolved in oil. Therefore, self-micro emulsifying drug delivery system (SMEDDS) was applied to improve drug solubility and bioavailability. In this study, PEG(MW=200, or 400), Labrafil, and Cremophor as cosurfactant, oil and surfactant were orderly mixed with Aceclofenac for formulation of SMEDDS. Droplet size of SMEDDS into water was determined 20~25㎚ size.(그림. 1) In vivo experiment was performed in rat at the pre-determined set time. we extracted serum from the rat and quantitatively analyzed drug concentration by HPLC. From these results, we could achieve the improved drug solubility and bioavailability using the SMEDDS.(그림. 2) Fig. 1. Particle size of SMEDDS. Fig. 2. Release test of Aceclofenac in vivo. Reference 1. N.Y. Hasan, M. Abdel-Elkawy, and B.E. Elzeany, Il Farmaco, 58, 91 (2003). 2. N.H. Zawilla, and N.M. El Kousy, J. Pharm. Bio. Anal., 27, 243 (2002). 3. R. A. Seymour, and J. Frame, B. J. oral. max. sur., 36, 375 (1998). |
| 저자 | 안용산1, 홍금덕2, 문대식1, 조선행2, 이종문1, 강길선1 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | Aceclofenac; SMEDDS; in vivo |
