| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.117 |
| 발표분야 | 생체적합성 유ㆍ무기 입자소재 |
| 제목 | Kinetic Approaches to the Preparation of Polymeric-Drug Nanoparticles |
| 초록 | The recent advance of polymer-drug nanoparticle engineering has widened the formulation opportunities of relatively water-insoluble drugs. The nanoparticles can be incorporated into all dosage forms including fast-melt, pulsed release and controlled release dosage forms with widening their application windows. Taste masking, longer dose retention in blood and tumors, reduction of fed/fasted variability, etc, are a few examples of numerous advantages of using drug nanoparticles. Methods to prepare drug nanoparticles can be categorized into two approaches, i.e., thermodynamic and kinetic approach. In the approaches, energy inputs or surface stabilization compensate the dramatic increase in surface energy (extra Gibbs free energy) accompanying with particle size reduction. In most processing, both the approaches are employed together. Herein, two major kinetic approaches, mechanical energy and electrical energy methods, will be discussed. The common mechanical energy sources are comminution, sonication, high energy flow (jet), etc. The methods can be easily adapted as a pharmaceutical unit operation, but labile drugs such as proteins may not be a proper drug candidate. On the other hand, electrical energy can successfully process labile drugs into various polymer-stabilized (or coated) nanoparticles without stability problems. 참고문헌 1. J. Lee. Drug nano- and microparticles processed into solid dosage forms: physical properties, J. Pharm. Sci. 92(10), 2057 (2003). |
| 저자 | 이종휘 |
| 소속 | 세종대 |
| 키워드 | Nanoparticles; Drug delivery; Formulation; Electrospray |
