| 초록 |
Phlorotannins are produced as second metabolites from brown algae. Their chemical structures are purely derived from phloroglucinol (1,3,5-trihydroxybenzene). The wide variety of their structures are generated by combinations of varied degree and regiochemistry of polymerization. Among them, a special class of phlorotannis with fused-ring structures (eckols) are abundantly found in Ecklonia cava and have shown great medicinal potentials. Based on currently available in vitro, in vivo and clinical studies, they have been shown to have excellent safety profiles and pharmacological potentials in many important areas including neurodegenerative diseases, cardiovascular diseases, metabolic diseases and cancer. Currently INDs for a botanical drug have been approved by US FDA and MFDS for clinical trias. This presentation reviews the pharmaceutical development status of this unique class of marine phytochemicals which shows a tremendous future industrial potentials. |
