| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Simultaneous control of cellular gene activation and its PEG-based hydrogel microenvironment via conventional LED light |
| 초록 |
In tissue engineering, providing an optimal cellular microenvironment has been considered to be a key criterion in designing scaffolds. Although incorporating responsive units has been able to develop cell-friendly niche, direct control of the microenvironment was limited. To address the limitation, light responsive linker has been introduced to hydrogel to directly modulate cellular microenvironment. From this approach, simultaneous temporal and spatial control of ECM degradation is possible, ultimately resulting in more precise direction of cellular activities. Additionally light responsive cells have been developed to manipulate cellular functions with a genetically encoded light-switchable transgene system. Finally, we encapsulated cells with light inducible dimerizing proteins for targeted gene control within a photodegradable PEG-based hydrogel scaffolds. Through blue LED light source, efficient gene control and scaffold remodeling system was enabled for tissue engineering. |
| 저자 |
Eunjee A Lee1, 허지승2, 선욱2, 황석연2
|
| 소속 |
1Seoul National Univ., 2서울대 |
| 키워드 |
gene control; biomaterials; optogenetics; hydrogels
|
| E-Mail |
|
