| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Tumor localized and photo-triggerable micelle-encapsulated drug to elicit synergistic therapeutic effects |
| 초록 | Recently, nanotechnology has received enormous attention due to their unique size and addible functional moiety according to needs. Regardless of these numerous platforms, undesired side effects such as normal tissue damage have been reported. To overcome these limitations, a combinatory chemo-photodynamic therapy has a synergistic potential to enhance antitumor effect as a promising strategy. Herein, we designed drug-incorporated photo-triggered micelles (DPTMs) based on a combination of ROS generator (RG) and ROS scavenger (RS) conjugated polymer to achieve effective drug delivery using a single depot. DPTMs were optimized and showed uniform morphology with nano-size. In addition, the ROS generation of DPTMs upon laser irradiation promoted the release of drug from micelles via reduction of RS. In this study, we demonstrated that DPTMs showed a higher therapeutic effect than monotherapy and confirmed a great potential for cancer treatment. |
| 저자 | 김다혜, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Photo-triggered; micelle; nanotechnology |
