| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Photo-mediated TRAIL gene loaded human mesenchymal stem cell for cancer therapy |
| 초록 | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising therapeutic protein to selectively induce cancer cell apoptosis. Because of denaturation, delivery of TRAIL protein exhibits low stability and short half-life. To deliver the TRAIL effectively to tumor site, human mesenchymal stem cells (hMSCs) were applied for the direct secretion of TRAIL to target tumors and use tumor homing effect. The TRAIL gene loaded stem cell was prepared by using non-viral vectors, but non-viral vectors induced hard to transfection. Thus, photochemical internalization (PCI) was utilized for enhanced transfection efficiency of secreting TRAIL from hMSCs. We demonstrate that PCI-mediated polyplex loading significantly enhanced TRAIL expression from stem cells and that homing ability magnified cancer targeting. Consequently, we implied that the delivery of PCI-polyplex@hMSCs offers exciting potential treatments in pancreatic cancer gene therapy. |
| 저자 | 이상희, 한지은, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | gene threapy; TRAIL; photochemical internalization; Stem cell; Cancer Therapy |
