| 초록 |
Last several years, technology with nano scale micelles has been drawn huge attention about disease treatment and diagnosis especially in cancer. In addition, among the stimuli, Reactive Oxygen Species (ROS) can control biological functions. On the oher hand, ROS could cause side effects or reduce therapeutic effect. Moreover, since the endosome and lysosome are known as the barriers, to escape endosome and lysosome would be important strategy.To solve the abovementioned problems, we fabricated light-dependent ROS producible micelle(LDRM) with photosensitizer(PS) that includes drugs. ROS were produced by PS at certain wavelength.After that, LDRM was changed their properties and facilitate drug release. At the same time, residual ROS at the cancer site assist drug to avoid endosome and lysosome. In vivo test, LDRM with irradiation presents therapeutic effects that reducing tumor size. As a result, LDRM shows enormous potential at therapeutic effect especially cancer and drug release. |
