| 초록 |
Drug delivery system has been progressed by many investigators to optimize the therapy of human diseases. The adequate devices for delivery the drug are required to achieve these goals. In this study, using the low molecular weight water soluble chitosan (LMWSC) with free amine group, hydrophobic drug loaded LMWSC nanoparticles were prepared by dialysis as modify with hydrophilic or hydrophobic group. The poly(ethylene glycol) (PEG) as hydrophilic group was introduced with the object of long ciuculation of nanoparticle in the blood and increasing hydrophilicity of carrier surfaces. Also, cholesterol, a hydrophobic group, can enhance the activity of the hydrophobic drug by formation of hydrophobic core of the chitosan-cholesterol derivatives. To identify of the nanoparticles loaded the drug, TEM observation and X-ray diffraction analysis were performed to compare with nanoparticle not loaded the drug. Also, zeta potential and critical aggregation concentration (cac) etc. were investigated. HPLC was used to measure the drug concentration in micellar solution.
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