| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
기능성 고분자 (포스터발표만 진행) |
| 제목 |
Versatile Fe3O4/Gold Core/Shell Nanocarriers for Near-Infrared Photothermal Therapy of Cancer |
| 초록 |
In this research, we synthesized hybrid Fe3O4 nanoparticles-Polystyrene/Gold core/shell nanoparticles, Fe3O4 NPs-PSt/Au NPs, via miniemulsion-emulsion combined polymerization and co-precipitation method. Fe3O4 NPs-PSt/Au NPs composition was confirmed by Fourier Transform Infrared Spectrometer (FT-IR). The crystalline structure of Fe3O4 NPs/Au nanocarrier was investigated by X–ray diffraction analysis (XRD). The Fe3O4 NPs-PSt, Fe3O4 NPs-PSt/Au NPs and Fe3O4 NPs/Au nanocarrier were confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. UV absorbance of Au shell was confirmed by UV-vis spectroscopy (UV-vis). In addition, diagnosis and treatment of cancer cells were implemented after injecting the nanocarriers into the HepG2 cells in an MTT assay. Finally, the strong contrast deriving from Fe3O4 NPs was demonstrated in phantom experiments for T2- andT2*-weighted images. |
| 저자 |
김용석, 임태극, 이혜원, 손우현, 고원건, 김중현
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| 소속 |
연세대 |
| 키워드 |
Fe3O4; gold; nanocarrier; theragnosis; photothermal therapy
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| E-Mail |
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