| 초록 |
Nanocapsules are being investigated as drug release vehicle, or specific carriers for gene delivery. Genistein was chosen a model drug, which is a antioxident agent. An positive moiety was incorporated to the PLGA to capsulate the genistein efficiently. The modified PLGA-genistein nanocapsules were prepared through a emulsion-evaporation method. The modified PLGA and genistein in acetone solvent were pured into the Tween 60 solution. Encapsulaion of genistein was achieved by the ionic interaction between anionic hydroxyl groups of genistein and cationic amine groups of modified PLGA. The content of genistein in nanocapsules and antioxidant activity of capsules were examined utilizing an HPLC and DPPH radical scavenging method, respectively. Depending on the concentration of cationic moiety in the modified PLGA, the in vitro release profiles of genistein was also investigated. |
